血液透析联合血液灌流治疗尿毒症皮肤瘙痒症的疗效.doc

血液透析联合血液灌流治疗尿毒症皮肤瘙痒症的疗效该论文来源于网络,本站转载的论文均是优质论文,供学习和研究使用,文中立场与本网站无关,版权和著作权归原作者所有,如有不愿意被转载的情况,请通知我们删除已转载的信息,如果需要分享,请保留本段说明。摘要:目的觀察尿毒症皮肤瘙痒症(UP)患者在血液透析(HD)联合血液灌流(HP)治疗的疗果。方法选取2016年6月~2017年6月雅安市第二人民医院血液透析中心诊断为UP患者40例,行HD联合HP治疗,共6个月。比较患者治疗前后四项目瘙痒(Four-itemItchQuestionnaire,FIIQ)量表评分、血白细胞(WBC)、全血红细胞(Hb)、血清肌酐(Cr)、血清尿素氮(Bun)、胱抑素C(Cys-C)、血清磷(P)、β2-微球蛋白(β2-MG)、甲状旁腺素(PTH)、C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平。结果HD联合HP治疗6个月后,36例(4例排除)患者WBC、Hb水平与治疗前比较,差异无统计学意义(P>);治疗后FIIQ量表评分、Cr、BUN、Cys-C、P、β2-MG、PTH、CRP、IL-6、TNF-α较治疗前降低,差异有统计学意义(P<)。结论HD联合HP有助于更好的清除UP患者体内的中小分子物质、调节水、电解质平衡,缓解UP患者的症状,值得借鉴。关键词:血液透析;血液灌流;尿毒症皮肤瘙痒症中图分类号::ADOI:.1006- 文章编号:1006-1959(2020)01-0118-03 binedwithHemoperfusionintheTreatmentofUremiaandSkinPruritus TANGJian,ZHUQian-ying,LIULi,XIANGQiao (HemodialysisRoom,Ya'anSecondPeople'sHospital,Ya'an625000,Sichuan,China) Abstract:ObjectiveToobservethetherapeuticeffectofuremiaandskinpruritus(UP)patientstreatedwithhemodialysis(binedwithhemoperfusion(HP).MethodsAtotalof40patientsdiagnosedasUPfromthehemodialysiscenterofYa'anSecondPeople'pareFour-itemItchQuestionnaire(FIIQ)scalescores,whitebloodcells(WBC),wholebloodredcells(Hb),serumcreatinine(Cr),serumureanitrogen(Bun),andcystatinCbeforeandaftertreatment(Cys-C),serumphosphorus(P),β2-microglobulin(β2-MG),parathyroidhormone(PTH),C-reactiveprotein(CRP),interleukin6(IL-6),tumornecrosisFactorα(TNF-α),thelevelsofWBCandHbin36(4excluded)patientswerenotsignificantlydifferentfromthosebeforetreatment(P>);FIIQscalescores,Cr,BUN,Cys-C,P,β2-MG,PTH,CRP,IL-6,TNF-αwerelowerthanbeforetreatment,thedifferencewasstatisticallysignificant(P<).binedwithHPishelpfulforbetterclearingofsmallandmediummolecularsubstances,regulatingwaterandelectrolytebalanceinpatientswithUP,andalleviatingsymptomsinpatientswithUP,whichisworthlearning. Keywords:Hemodialysis;Hemoperfusion;Uremiaskinpruritus 尿毒症患者中超过50%有皮肤瘙痒症(uremicpruritus,UP)[1],发病机制复杂,有研究认为[2],UP与血液透析难以将体内产生的瘙痒代谢产物清除及白细胞介素6(IL-6)、肿瘤坏死