Lecture 11 Molecular Design and Synthesis of Biomaterials III Inorganic Biomaterials.pdf

Molecular Principles of Biomaterials Spring 2003

Lecture 11: Molecular Design and Synthesis of Biomaterials III: anic
Biomaterials



Last time: hydrogel applications: molecular imprinting and responsive drug delivery

Today: biomineralization and biomimectic posites
anic biomaterials

Reading: . Estroff and . Hamilton, ‘At the interface anic and anic chemistry:
bioinspired synthesis posite materials,’ Chem. Mater. 13, 3227-3235 (2001)

Stephen Mann, ‘Biomineralization: Principles and Concepts in anic Materials
Chemistry,’ Ch. 5 pp. 68-88, Oxford Univ. Press (2001)



• 1 million orthopaedic surgeries involving bone grafting materials each year in US (R. Langer et al. Tissue Eng., 1,
151 (1995))
o autografting is best but limited in the size of defects that can be corrected (J. South Orthop ssoc. 9, 91
(2000); Aust N Z J Surg. 69, 726 (1999))
o allografting presents possibility of disease transmission (HIV, hep B) (S. Mendenhall; Commetnary: the
bone graft market in the United States, in Bone engineering . Davis, ed., em squared incorporated
2000, Torotonto, Canada p. 585-590)
o synthetic solid hydroxyapatite resorbs very slowly (Clin Orthop. 157, 259 (1981))

Bone Tissue Engineering:
JBRM 29, 359 (1995) Ca phosphate
JBMR 36, 17 (1997) PLGA
Biomaterials 19, 1405 (1998) PLGA
J Biomat Sci-polym ed, 7, 661 (1996) PLGA-Ca posite
Test

Biomineralization and biomimetic anic crystals1

Structure and synthesis mechanisms of biomimetic anic crystals2-4

• motivation for studying biomineralization
o natural anization, anic molecules (peptides and proteins) guiding anic
crystal growth, allows shapes that defy the classical 230 space groups of crystalline materials
o biomineralization processes vs. laboratory methods
• Biological methods - benign synthesis methods
1. Precisely control upon morphologies and structures over several length scales