Cell Signaling
一、General Principles of Cell Signaling 二、Signaling Mediated by Intracellular
Receptors
三、Signaling Mediated by Cell-Surface
Receptors
Grey boxes: ponents
of signaling pathways
White boxes: specific examples
Ligand
Receptors
Intracellular mediators
Nuclear events
Nature 411: 759 (2001)
Cell Signaling
一、General Principles of Cell Signaling 二、Signaling Mediated by Intracellular
Receptors
三、Signaling Mediated by Cell-Surface
Receptors
1. Ion-Channel-Linked Receptors
离子通道型受体(Ion-Channel-Linked Receptors)及其信号转导
A Model for the Structure of the Nicotinic(烟碱型) Acetylcholine Receptor
Five homologous bine to form a transmembrane aqueous pore.
In its closed conformation, the pore is thought to be occluded by the hydrophobic side chain of five leucine residues which form a gate near the middle of the lipid bilayer.
Yellow: Leu residues
Blue: polar residues
Cell Signaling
一、General Principles of Cell Signaling 二、Signaling Mediated by Intracellular
Receptors
三、Signaling Mediated by Cell-Surface
Receptors
1. Ion-Channel-Linked Receptors
2. G-Protein-Linked Receptors or
G-Protein-Coupled Receptors (GPCR)
G蛋白偶联型受体及其信号转导
G蛋白偶联型受体:七次跨膜受体
信号传递的基本过程:
信号转导2 来自淘豆网m.daumloan.com转载请标明出处.
