Analysis of Protein Geometry, Particularly Related to Packing at ....ppt
BIOINFORMATICS Introduction Mark Gerstein, Yale University
What is Bioinformatics? (Molecular) Bio - informatics One idea for a definition? Bioinformatics is conceptualizing biology in terms of molecules (in the sense of physical-chemistry) and then applying “informatics” techniques (derived from disciplines such as applied math, CS, and statistics) to understand anize the information associated with these molecules, on a large-scale. Bioinformatics is “MIS” for Molecular Biology Information. It is a practical discipline with many applications. Organizing Molecular Biology Information: Redundancy and Multiplicity Different Sequences Have the Same anism has many similar genes Single Gene May Have Multiple Functions Genes are grouped into Pathways Genomic Sequence Redundancy due to the ic Code How do we find the similarities?..... (idea from D Brutlag, Stanford) Integrative Genomics - genes structures functions pathways expression levels regulatory systems …. A Parts List Approach to Bike Maintenance A Parts List Approach to Bike Maintenance What are the shared parts (bolt, nut, washer, spring, bearing), unique parts (cogs, levers)? What are mon parts -- types of parts (nuts & washers)? How many roles can these play? How flexible and adaptable are they mechanically? Where are the parts located? General Types of “Informatics” techniques in Bioinformatics Databases Building, Querying Object DB Text parison Text Search 1D Alignment Significance Statistics Alta Vista, grep Finding Patterns AI / Machine Learning Clustering Datamining Geometry Robotics Graphics (Surfaces, Volumes) Comparison and 3D Matching (Visision, recognition) Physical Simulation Newtonian Mechanics Electrostatics Numerical Algorithms Simulation New Paradigm for puting Because of increase in data and improvement puters, new calculations e possible But Bioinformatics has a new style of calculation... Two Paradigms Physics Prediction based on
Analysis of Protein Geometry, Particularly Related to Packing at ... 来自淘豆网m.daumloan.com转载请标明出处.
