PREPARATION and CHARACTERIZATION of CHITOSAN MICROSPHERES ENCAPSULATING IC Fe3O4 NANOPARTICLES
Benjamin Teong, Shwu Jen Chang, Ioannis Li Chun Lin Manousakas, Shyh-Ming Kuo Department of Electrical Engineering, Orthopedic Department of Biomedical Engineering Department I-Shou University Veteran General Hospital Kaohsiung, Taiwan Kaohsiung, Taiwan
Abstract—Chitosan microspheres (Chi-Fe microspheres) encapsulating ic iron oxide nanoparticles Chitosan a natural haride obtained by alkaline (SPION, Fe3O4) were produced using a high voltage electrostatic deacetylation of chitin contents that constitute the shells of field system. The surface morphology and size of these prepared crab or shrimp [3]. Because of its patibility, chitosan Chi-Fe microspheres were examined using optical microscopy has shown great potential in a number of biomedical and scanning electron microscopy. The preliminarily results applications including drug delivery system and wound showed that the size of the Chi-Fe microspheres was at the range of 600 μm in diameter, however, the surface morphologies could dressing [3]. Moreover, chitosan has been explored be changed by treating with different ratios of crosslinking extensively to prepare microspheres for a controlled release system. solution. The formulation with ratio of 17:3 (Na5P3O10: NaOH) had a sm
