奥沙利铂联合亚叶酸钙及氟尿嘧啶治疗晚期大肠癌.pdf

奥沙利铂联合亚叶酸钙及氟尿嘧啶治疗晚期大肠癌曾志文谭丽华王红南昌市第三医院(南昌330009) 摘要:目的:观察奥沙利铂联合亚叶酸钙及氟尿嘧啶方案治疗晚期大肠癌的临床疗效及毒副反应。方法:32例晚期大肠癌患者给予化疗方案为:奥沙利铂L-OHP130mg/m2静脉点滴,2h,d1;亚叶酸钙CF200mg/m2,静脉点滴,2h,d1;氟尿嘧啶5-FU400mg/m2静脉推注, 后2400mg/m2微泵持续静脉滴注48h;每2周重复,4周为1个周期,完成2个周期后判定疗效,按WHO标准评价客观疗效和毒副反应。结果:全组32例均可评价疗效,其中完全缓解 CR4例,部分缓解PR12例,稳定SD9例,进展PD7例,总有效率CR+%。,。毒副反应主要是骨髓抑制,胃肠道反应及外周神经毒性。结论:奥沙利铂联合亚叶酸钙及氟尿嘧啶方案治疗国人晚期胃癌的近期疗效较好,毒副反应可以耐受,值得进一步研究应用。关键词:晚期大肠癌;奥沙利铂;亚叶酸钙;氟尿嘧啶;化疗 Treatmentofadvancedcolorectalcarcinomawiththe binationwithCF、5-FU [Abstract]binedwithleu covorinand5- tientswithadvancedcolorectalcarcinomaweretreatedwithchemotherapyofregimen:oxaliplatin 130mg/m2,ivgtt,d1;CF200mg/m2ivgtt2hfollowedby5-Fu400mg/m2(bolus)and5-Fu 2400mg/m2(48h-coutinousinfusion)andrepeatedevery2weeks, pleteremissionCR,12patientspartialremissionPR,9pat(i)entsstabledis easeSD,%.Themediantime toxicityincludedleucopenia,nausea, binationwithCF、5-FUisef fectiveandtolerableinadvancedcolorectalcarcinoma. [KeyWords] ancer;Oxaliplatin;Leucovorin; 5-fluorouraci; Chemo therap