The discussion on the application of rotary total heat exchanger in the laboratory animal environment of SPF Han Junzhao1 Jiao Hongzhao2 (1 School of Research and Design, Changchun Institute of Technology, Changchun 130012, China;2 Henan artisan international construction planing and design consultant Co.,Ltd. Zhengzhou 450007, China) 【Abstract】 The problem that the energy consuming is huge and the running cost is high in the laboratory animal environment of SPF at present was analyzed. The solution of cross pollution caused by rotary total heat exchanger was proposed. Comparing the rotary total heat exchanger to plate heat exchanger in economic, the conclusion is that the economical efficient of rotary total heat exchanger is obvious and the rotary total heat exchanger can be applied in air-conditioning system of the laboratory animal room of SPF. 【Keywords】 air-to-air total heat exchanger; cross pollution; sterilizati