国产头孢呋辛在慢性肾脏病不同肾功能阶段病人的药代动力学的分析研究.pdf

·中文论著摘要· 国产头孢呋辛在慢性肾脏病不同肾功能阶段病人的药代动力学研究目的本试验研究国产头孢呋辛在7名不同肾功能阶段慢性肾脏病患者的药代动力学。方法患者根据CKD分期分成两组(;),采用高效液相色谱法测定单次静脉滴注1000 mg头孢呋辛后,不同时刻血浆中头孢呋辛的血药浓度,。,采用 DAS 。同时,测定不同时间段的尿药浓度, 计算尿药累积排泄率。++, + {-,AUC(+·h/ml和 ·h/ml,AUC(+·+·h/ml。CLz - ml/+,++ L。 +%+%。结果表明:两组肾功能损伤程度不同,对其药代动力学参数影响不同(P<),主要表现在药物清除半衰期tl/2、药物清除率CLz、曲线下面积AUC。结论本研究表明慢性肾脏病患者肾功能阶段不同对头孢呋辛的药代动力学参数影响不同,临床应用时要根据肾损伤程度调整药物剂量,,避免肾毒性的发生。关键词头孢呋辛,药代动力学,慢性肾脏病高效液相色谱法 2 ·英文论著摘要· ics ofdomestic cefuroxime inpatients with chronic kidney disease ofdifferent stages of renal function Obj ecctive The ics ofdomestic Cefuroxime was investigated in7patients withchronic kidney disease ofdifferentstages ofrenalfunction Methods Patients were divided intotwo groups according toCKD stages(CKD2·3 were gr—oup 1,CKD4-5 were group 2、.cefuroxime concentration indifferenttime were measure—d inplasma by HPLC after a single intravenous atdose of 000 mg domestic blood concentration-time curve and according to the plasma concentration·time data we calculated the main ic parametersby DAS - thesametime,urinesamples were collected at different intervals and measured urine drug concentration to calculate the cumulative urineexcretion rate Results The main ic parameters oftwo groups were asfollowigs:Cm弘 were()and()ug/ml,tl/2were(-j:)and() h,AUC(o-t)were(:)and()ug·lgml,AUC(( )and(+)ug·h/ were(+)and(0。97+)ml/mi-n,Vz were()and()L, 2hurine excretion accounted %+%。The resultsshowed thatstatistically significant differences between ic parameters oftw