自然周期和微刺激方案在卵巢低反应患者ivf-et的临床应用.pdf

中南大学七年制硕士学位论文中文摘要摘要目的:()在卵巢低反应患者的应用效果。方法:对中南大学附属湘雅医院生殖医学中心2005年1月至2008年12 月122名患者共169个发生卵巢低反应的IVF周期进行临床资料的回顾性分析。结果:①小于40岁患者应用自然周期和微刺激方案的有33个起始周期, %,%,%,%;应用改良短方案的有87个起始周期,取消率为 %,%,%,%。两种方案取卵周期获卵率、取卵周期移植胚胎率、移植周期临床妊娠率相比无显著差异(P<)。②40岁以上患者应用自然周期和微刺激方案的有23个起始周期,%,%,%,未获临床妊娠;应用改良短方案的有26个起始周期, %,取卵周期获卵率为100%,%,%。两种方案取消率、取卵周期获卵率、取卵周期移植胚胎率、移植周期临床妊娠率相比均无显著差异(P<)。结论: 岁患者是一种经济、简单有效的治疗方法。关键词自然周期,徼刺激,卵巢低反应, ABSTRACT Methods:A method ofretrospective study thatused intheclinical document of122patients with poor response who undergone 169cycles ininvitro fertilizationandembryo transferfrom intheReproductive Medicine Centre ofXiangYa Medical Sch001. Result:(1)<40 years old:33 poor responders underwent IVF cycles using natural and mini-stimulation protocol,cancelled cycle rate was %,essful oocyte retrievals rate was %,percentage of embryo transfers perattempted oocyte retrieval Was 76,20%,clinical pregnancy per transfer cycle was %;87 poor responders underwent IVF cycles using ashort 7-day gonadotropin·releasing hormone agonist (GnRH—a)protocol,cancelled cycle rate was %,essfuloocyte retrievals ratewas %,percentage ofembryo transfers perattempted oocyte retrieval was %,clinicalpregnancy per transfer cycle was %.Thedifference ofoocyte retrievals rate,percentage ofembryo transfers per attempted oocyte retrieval and clinical pregnancy per transferswere notsignificant between thetwoprotocols(P<). (2)-->_40years old:23 poor responders underwent IVF cycles using naturaland mini—stimulation protocol,cancelled cycle %, essful oocyte retrievals rateWas %,percentage ofembryo transfers per attempted oocyte retrieval was %and didn’tobtain clinicalpregnancy;26 p