Inhibitory Effect of Citrus Nobiletin on Phorbol Ester-induced
Skin Inflammation, Oxidative Stress, and Tumor Promotion Yutaka Sashida, Susumu Kitanaka, and Hajime Ohigashi2
Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki University, Wakayama 649-6493 [A. M., T. K., K. K.]; Division of Applied
Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502 [Y. N., K. T., H. O.]; First Department of Pathology, Kanazawa Medical University, Ishikawa
920-0293 [T. T.]; Research and Development Division, Wakayama Agricultural Processing Research Corporation, Nagagun, Wakayama 649-6112 [S. K., Y. T.]; Department of
Citriculture, Fruit Tree Research Station, Shizuoka 424-0292 [K. O., M. Y.]; Department of Biochemistry, Kyoto Prefecture University of Medicine, Kyoto 602-0841 [H. T.,
H. N.]; Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo 192-0392 [Y. M., Y. S.]; and Laboratory of
Pharmacognosy, College of Pharmacy, Nihon University Chiba 274–8555 [S. K.], Japan
3 Ϫ
ABSTRACT TPA -induced O2 and hydroperoxide production and inhibited s
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