多西他赛说明书.pdf

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HIGHLIGHTS OF PRESCRIBING INFORMning complications. Obtain LFTs before twice a day) for 3 days starting 1 day before administration
each treatment cycle ( )
• HRPC: oral dexamethasone 8 mg, at 12, 3, and 1 hrs before treatment
• Should not be given if neutrophil counts are < 1500 cells/mm3. Obtain
frequent blood counts to monitor for neutropenia ( 4) Dosage adjustments during treatment see full prescribing information ( )
• Severe hypersensitivity, including very rare fatal anaphylaxis, has been
---------------------DOSAGE FORMS AND STRENGTHS----------------------
reported in patients who received dexamethasone premedication. Severe
reactions require immediate discontinuation of TAXOTERE and • Single dose vial 80 mg/2 mL and diluent, 20 mg/ mL and diluent ( 3)
administration of appropriate therapy ( )
-------------------------------CONTRAINDICATIONS------------------------------
• Contraindicated if history of severe hypersensitivity reactions to
TAXOTERE or to drugs formulated with polysorbate 80 ( 4) • Hypersensitivity to Taxotere or polysorbate 80 ( 4)
3 ( 4)
• Severe fluid retention may occur despite dexamethasone ( ) • Neutrophil counts of < 1500 cells/mm
-----------------------WARNINGS AND PRECAUTIONS------------------------
----------------------------RECENT MAJOR CHANGES--------------------------
• Acute