rate of the study group was % higher than that of the control group (%) (P < ). Compared with the control group after treatment, the contents of bifidobacteria and Lactobacillus in the study group were significantly increased, while the contents of Escherichia coli were significantly decreased (P < ); After treatment, the levels of inflammatory factors in the study group were lower than those in the control group (P < ). After treatment, the levels of immune function indexes in the study group were higher than those in the control group (P < ). Conclusion: Mesalazine, bifidobacterium triple viable capsule and Changyanning capsule have significant effect on UC patients, which can regulate intestinal tract, improve immune function and reduce inflammatory state. Key words: Bifidobacterium triplet viable capsule; Mesalazine; Yanyanning capsule; Ulcerative colitis; Curative effect; Intestinal flora