Evaluation on the efficacy of moxifloxacin hydrochloride based on physiological pharmacokinetic models
GAO Jie1,2, FENG Fang2, WANG Li-xin1, CHONG Xiao-meng1, WANG Chen1*, YIN Li-hui1* (1. National Institutes for Food and Drug Control, Beijing 102629, China; 2. China Pharmaceutical University, Nanjing 210009, China)
Abstract: This study is to establish and validation in vivo models of moxifloxacin based on the theory of physiologically based pharmacokinetics (PBPK), and then to 1predict the distribution of moxifloxacin in human venous return and organ such as lung, reproductive and so on. The efficacy of moxifloxacin and its pharmaceutical preparations were quantified by comparing the pharmacokinetic parameters with the minimum inhibitory concentration of related pathogenic bacterium. The results showed that the anti-infection efficacy of pharmaceutical moxifloxacin preparation in the corresponding organs was basically the same. The PBPK model of moxifloxacin preparations can be more accurately described the pharmacokinetic of anti-infective drugs in human, it
