Tob mRNA在结直肠癌组织表达的临床病理学意义.doc

临床医学论文-Tob mRNA在结直肠癌组织表达的临床病理学意义
              作者:霍志斌, 王淑霞, 吴殿超, 肖琦海, 翟同善, 周总光
【关键词】  结直肠癌
  摘     要:目的:研究Tob mRNA在结直肠癌组织及其相应的癌旁正常组织的表达,探讨其在结直肠癌发生发展中的作用。方法:用荧光定量RT-PCR方法,检测38例结直肠癌标本及其相应的癌旁正常组织Tob mRNA的表达。结果:38例癌组织Tob mRNA表达高于癌旁正常组织(P<); Tob mRNA表达随着Dukes分期有增高趋势,差异有统计学意义(P<)。结论:在结直肠癌的发病机制中,Tob mRNA可能为致癌基因。
关键词:     结直肠癌;     Tob mRNA
Association of Tob mRNA Expression with Clinicopathological Characteristics of Colorectal Cancer
Abstract: Objective: To investigate the expression of Tob mRNA in human colorectal cancer tissues, and their corresponding para-cancerous tissues , and to investigate the role of Tob mRNA in the pathogenesis of colorectal cancer. Method: Quantitative real time RT-PCR was used to detect the expression of Tob mRNA in 38 colorectal cancers. Result: Compared to those from corresponding normal tissues the expression of Tob mRNA in  colorectal cancer tissues were significantly increased. Moreover, the expression value of Tob in Dukes A,B,C,D was ±, ±, ± and ±,respectively. Analyzed by one-way ANOVA,there were significant differences in the expression of Tob in defferent Dukes stage. Conclusion: The up-regulation expression of Tob mRNA may be closely associated with tumorigenesis of colorectal carcinoma.
Key words:     Colorectal cancer;     Tob mRNA
Tob基因是抗增殖基因,可抑制细胞的增殖[1],最近的研究表明:在肺癌的发病机制中Tob可能为抑癌基因[2]。