吡喹酮透皮给药治疗日本血吸虫病研究分类号密级华中农业大学硕士学位论文 Study on Treatment of Schistosomiasis Japanum with Praziquantel via Skin 研究生: 段存争指导教师: 郑新生教授专业:农药学获得学位名称:农学硕士研究方向:药物剂型获得学位时间: 2008 年6月华中农业大学理学院二○○六年六月摘要.......... ................................................................................................................ 3 Abstract ................................................................................................................. ....4Ⅰ前言......................................................................................................................... ....5 日本血吸虫病及防治现状..................................................................................... 5 血吸虫病概述.... ......................................................................................... 5 . 1 血吸虫的生活史................................................................................ 5 血吸虫病发病机理及临床症状...................................... ..................... 5 我国血吸虫病现状............................................................................ 6 血吸虫病防治药物研究概况........................................................................ 8 透皮给药概述...................... .............................................................................. 10 透皮给药的发展史.................................................................................... 10 透皮促进方法概述................................................... ..................................11 化学促透方法..................................................................................11 物理方法........................................................................................ 12 吡喹酮治疗血吸虫病概述................................................................................... 14 吡喹酮概述.............................................................................................. 14 NOO ..................................................................................... 14 吡喹酮体内代谢.....
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