缬沙坦氨氯地平联合治疗原发性高血压-j.pdf

ORIGINAL PAPER
Combination therapy with amlodipine/valsartan
in essential hypertension: a 52-week, randomised,
open-lAEs) and mean sitting systolic BP (MSSBP) ⁄ mean sitting
tolerated in short-term studies. Correspondence to:
diastolic BP (MSDBP) £ 150 ⁄ 95 mmHg were eligible to enter the extension and be Timothy R. Smith, MD, RPh,
treated with Aml ⁄ Val ⁄ 80 or 5 ⁄ 80 mg. After 4 weeks of treatment, patients What’s new FACP
underwent force-titration to receive 5 ⁄ 160 mg (low dose) or 10 ⁄ 160 mg (high This 52-week, multicentre, open-label study Mercy Health Research, 12680
provides additional information on the long-term Olive Boulevard, Suite 200,
dose) for 48 weeks. Addition of hydrochlorothiazide (HCTZ) mg was permit-
administration of the combination of St Louis, MO 63141, USA
ted if BP was ‡ 140 ⁄ 90 mmHg at Week 8 or later. Patients could be down-
amlodipine ⁄ valsartan. Combination therapy at Tel.: +1 314 251 8890
titrated to the prior lower combination dose with or without HCTZ if an intolerable doses of 5 ⁄ 160 and 10 ⁄ 160 mg provided Fax: +1 314 251