还原型谷胱甘肽治疗脓毒症急性肾损伤的效果.pdf

中国医药导报2022年3月第19卷第9期 •临床医学-泌尿系统疾病-
还原型谷胱甘肽治疗脓毒症急性肾损伤的效果
lde­
hyde (MDA), and total antioxidant capacity (TAOC) in both groups were observed. Results After treatment, serum crea­
tinine (Scr), Cystatin C (Cys-C), and serum neutrophil gelatinase-associated lipocalin (sNGAL) in the two groups were
lower than those before treatment, Cys-C and sNGAL in the observation group were lower than those in the control
group (P < ). After treatment, MDA in both groups was lower than that before treatment, and TAOC was higher than
that before treatment, and MDA in observation group was lower than that in control group, and TAOC in observation
group was higher than that in control group (P < ). Conclusion Reduced glutathione can improve the antioxidant
capacity of the body, and promote the recovery of patients with sepsis acute kidney injury.
[Key words] Reduced glutathione; Sepsis; Acute kidney injury; Neutrophil gelatinase -associated lipocalin; Malondi­
aldehyde; Total antioxidant capacity
脓毒症作为一种急诊危重症，其发病机制涉及感 症患者会发生急性肾损伤(acute kidney injury,AKI),
染、免疫、组织损伤、机体炎症等,可导致多系统、多器 %。AKI已被证实为脓毒症患者病死率
官病变［1］，其中肾脏是最容易受累的器官之一。国外一 的独立危险因素,即使患者肾功能轻度受损也可增加