吲哚布芬对急性脑梗死治疗临床研究.doc

吲哚布芬对急性脑梗死治疗的临床分析
杨琨孙佳凡
山西省中西医结合医院神经内科
Clinic Analysis of Treatment on the Acute Ischemic Stroke with Indobufen
Yang-kun Sun-jiafan
Department of Neurology,Shanxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Taiyuan 030013,China;
〔Abstract〕Objective To investigate the effects and safety of Xinbei- indobufen in patients with acute ischemic stroke disease. Methods 170 patients with acute ischemic stroke were selected and randomly divided into experiment group (n=82) and control group (n=88). The patients in experiment group were given anti-platelet indobufen (200mg, bid) and others in control group were given aspirin (100mg, qd) for 6 weeks. Platelet aggregation, the score of neurology impairment and adverse effects pared between the two groups. Results: After treatment, the platelet aggregation in both groups were lower at 2-week and 6-weeks than before (P<). The score of neurology impairment in the both groups were improved at the 6-weeks (P<). There was no significant difference in the platelet aggregation and the score between experiment group and control group (P>).Drug related serious adverse effects were not found in the experiment group. Conclusion Indobufen may reduce significantly platelet aggregation on the patients with acute ischemic stroke. The effect on anti-platelet of indobufen was equal to one of aspirin. Indobufen