新型狂犬疫苗的介绍.ppt

第五小组成员:张曼玲谢泳瑶马炎威谢晓泽
Safety and serological response to a matrix gene-deleted rabies virus-based ine vector in dogs
狂犬疫苗安全的血清学反应
期刊文献来源:
ence/article/pii/S0264410X14000772
Highlights
A replication-deficient(复制缺陷型) rabies virus-based ine is proposed as a new ine against canine rabies virus.
RABV(复制缺陷型狂犬疫苗)是一种新型的疫苗,可以用于预防狂犬病。
The replication-deficient rabies virus-based ine was safe in inated dogs.
狂犬疫苗是安全的。
Rapid and potent virus neutralizing antibodies were induced in dogs immunized with the replication-deficient rabies virus-based ine.
犬只接受狂犬疫苗的免疫后在体内产生了快速高效的病毒中和抗体。
Result
Immunization of dogs with RABV-ΔM does not result in systemic or local adverse events.
犬接受狂犬疫苗的免疫不会造成全身或局部的不良反应。
Immunization with RABV-ΔM results in long lasting effective anti-RABV immunity in dogs.
犬在接受狂犬疫苗免疫后,在体内会产生长期有效的病毒抗体。
发明狂犬病疫苗的路易·巴斯得(Louis Pasteur)
狂犬病(rabies)即疯狗症,又名恐水症,是一种人畜共通传染病,病原体为狂犬病病毒(Rabies virus,RABV)。病毒大量存在于发病者的脑脊液、唾液和体液中,绝大部份通过咬伤传播,很多时令染病的人或动物特别活跃,在没