紫杉醇联合奥沙利铂治疗晚期胃癌27例疗效观察.doc

紫杉醇联合奥沙利铂治疗晚期胃癌27例疗效观察
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紫杉醇联合奥沙利铂治疗晚期胃癌27例
疗效观察
(作者:___________单位: ___________邮编: ___________)
【摘要】目的:探讨紫杉醇联合奥沙利铂治疗晚期胃癌的疗效和毒副作用。方法: 27例晚期胃癌患者均给予紫杉醇137~175 mg/m2,第1天持续静脉泵入3 h,奥沙利137~175mg/m2;第2天持续静脉泵入2 h,21 d为1周期,平均用药3~4周期。结果:全组27例均可评定疗效,获完全缓解(CR)1例、部分缓解(PR)15例、稳定(SD)6例、进展(PD)5例, %,%;对腹膜后淋巴结转移疗效最好,%;主要毒副作用为骨髓抑制,神经毒性等。结论:紫杉醇联合奥沙利铂治疗晚期胃癌患者疗效较好,毒副作用轻,患者可耐受,值得临床推广应用。
【关键词】胃癌;紫杉醇;奥沙利铂;化学治疗
Objective: To explore the efficacy of bination of paclitaxel and oxaliplatin on advanced gastric cancer and its toxicity and side effects. Methods: 27 patients with advanced gastric cancer were treated with paclitaxel (137 mg/m2175 mg/m2 ) and oxaliplatin
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day. 21 days of treatment was considered as a course and the average procedure for all patients was 3 to 4 : According to the efficacy assessment, 1 out of the 27 cases was evaluated plete remission, 15 were evaluated as partial remission, 6 as stable disease and 5 as progression disease. The total effective rate was %, clinical inhibition rate was %. The treatment showed the best effects on retroperitoneal lymph node metastasis cases with efficiency of %. The main toxicity were myelosuppression and neurological toxicity. Conclusion: binat