凝血酶与肿瘤转移论文.doc

凝血酶与肿瘤转移论文.doc凝血酶与肿瘤转移论文
孟宇宏,虞积耀,陆应麟
【摘要】凝血酶是一种多功能丝氨酸蛋白酶,在体内一系列生理和病理过程中起重要作用。它不但参与止血和凝血、炎症、免疫反应、组织修复和创伤愈合,而且可激活正常细胞的致瘤潜能和导致恶性细胞的转移表型。凝血酶是肿瘤细胞的促有丝分裂剂,能够增强肿瘤细胞对细胞因子的增殖反应,增强肿瘤细胞对血小板的黏附及体外细胞基质的侵袭,促进肿瘤血管形成和肿瘤微环境的组织重建。凝血酶受体家族 PARs介导凝血酶的细胞生物学效应。凝血酶对肿瘤细胞生长具有双向调控作用,低浓度者促进生长, and Tumor Metastasis ——Reviebin is a multifunctional serine protease that plays a key role in a variety of physiological and pathological conditions. In addition to the role in hemostasis and coagulation, thrombin has other numerous biological activities affecting inflammation, immune responses, tissue repair and its physiological role thrombin activates the oncogenic potential of both normal and malignant cells and leads a metastatic phenotype. It is a potent mitogen for many tumor cells. It potentiates the proliferative response of tumor cells to some groor cells to the extracellular matrix, enhances the metastatic capacity of tumor cells,activates angiogenesis and remodels the microenvironment of the tumor. The cellular biological effects of thrombin are mediated at least in part by a neily of Gproteincoupled receptors designated proteinaseactivited receptors(PARs). Thrombin has a bilateral effect on tumor cells:enhanced gropaired grobin, thrombin and tumors, and thrombin receptors etc bin; tumor ;metastasis
侵袭和转移是恶性肿瘤的基本生物学特征,也是肿瘤患者死亡的主要原因。肿瘤的侵袭和转移是肿瘤细胞、宿主细胞和组织微环境之间一系列复杂、多步骤、多因素、多功能的相互作用的序贯连续过程。此过程涉及到