皮肤脂溢性角化病发病机理探讨.doc

皮肤脂溢性角化病发病机理探讨
徐华苏旭
[摘要]目的,探讨皮肤脂溢性角化病的发病机理,方法:收集成都市第五人民医院病理科收集的22例皮肤脂溢性角化病的临床病理资料,进行光镜观察和免疫组织化学EAVision 法染色光镜观察,复习相关文献,结果22例患者女性10例、男性12例、发病年龄44岁—81岁,,病变最大径为2 cm。镜下观察,基底样细胞增生伴有不同程度的鳞状细胞分化,分为棘细胞型,网球型,色素型,克隆型,液型,高化过度型,扁平型,免疫组化染色20例脂溢性角化病的增生的基底样细胞层见HPV染色阳性。结论:皮肤脂溢性角化病的发病机理主原是由于皮肤受损后感染人乳头状瘤病毒所致。
[关键词]皮肤脂溢性角化病发病机理感染病毒
The Pathogenesis of Seborrheic Keratosis of the Skin
Xu Hua, Su Xu
Abstract: Objective To explore the pathogenesis of seborrheic keratosis skin. Methods The data of 22 cases of seborrheic keratosis skin in the first fifth people’s hospital of Chengdu were collected and observed by light microscope and immunohistochemical EAVision method. Results Of the 22 cases, 12 cases were male and 10 cases female, aging from 44 to 81, with an average age of ; the lesions in the biggest diameter is 2 cm. Under microscopic observation, basaloid cells proliferation has different degrees of squamous cell differentiation, such as acanthocyte, tennis, pigment, KeLongXing, fluid type, transitional type and high flat; the basal cell layer of the 20 seborrheic keratosis cases’ sample hyperplasia shows, after immunohistochemical staining, HPV positive staining. Conclusion The pathogenesis of seborrheic keratosis skin was caused by the infection of human papilloma virus after after skin damage.
Key words: seborrheic keratosis; pathogenesis; infection; vi