Cell Metabolism
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Exercise Controls Non-Coding RNAs
Shizuka Uchida1,2 and Stefanie Dimmeler1,2,*
1Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, D-60590 Frankfurt, Germany
2German Center for Cardiovascular Research, Partner side Rhein-Main, D-60590 Frankfurt, Germany
*Correspondence: ******@-
http://dx./.
The mechanisms by which exercise regulates physiological cardiac growth and protects against maladaptive
remodeling of the heart have been long sought after. In this issue, Liu et al. (2015) report that microRNAs are
important regulators of exercise responses in the heart.
Experimental and clinical studies have linked to the growth and proliferation of In line with the need for the cell-type-
shown that exercise keeps the heart cardiomyocytes, such as p27, Hipk1, specific targeting of miR-222, exercise
healthy. Exercise induces many changes and Hmbox1, as miR-222 targets (Fig- appears to induce a cell-specific regula-
in signaling pathways, which lead to ure 1). Since exercise-modulated gene tion of miR-222. Although miR-222 was
changes in gene works works might protect the induced in cardiomyocytes, a reduction
that are distinct from the pathophysiolog- heart from injury and maladaptive remod- (although not statistically significant) was
ical response to pr
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