头孢米诺钠治疗62例产ESBLs细菌感染的临床疗效观察.doc

头孢米诺钠治疗62例产ESBLs细菌感染的临床疗效观察
【关键词】头孢米诺钠,ESBLs,疗效
【摘要】目的评价头孢米诺钠治疗产超广谱β-内酰胺酶(ESBLs)细菌感染的疗效及不良反应。方法采用自身对照的方法,比较用药前后疗效改变及菌种变化。结果头孢米诺钠治疗产ESBLs细菌感染的有效率为94%,其细菌清除率为92%,不良反应少。结论头孢米诺钠是目前治疗产ESBLs细菌感染较理想的药物。

Treatment e of cefminox sodium against infection of ESBLs

He Ruowen,Liu Liangan

Huizhou Central Hospital,Guangdong516001.

【Abstract】 Objective To study clinical therapeutic effect and side-effects of cefminox sodium on treating infection of 62cases were investigated by self-controlled method with cefminox sodium;changes in pathogenic strains and therapeutic effect pared before and after applying cefminox The total effective rate was94%,and bacteria clearance rate was92%while transient side-effects were
-sion Cefminox sodium is an effective drug against infection of ESBLs.

Key words cefminox sodium ESBLs therapeutic effect

随着抗菌药物的广泛应用,产超广谱β内酰胺酶(ex-tended spectrumβ-lactamases,ESBLs)菌株已逐渐引起临床医生的关注。头孢米诺钠(cefminox sodium)属头霉素类抗生素,具有生物利用度高、疗效较好的特点。2003年12月~2004年12月,我科用该药治疗产ESBLs细菌感染病例62例,临床有效率达94%,现报告如下。
1 资料与方法

一般资料本组62例均为住院患者,男38例,女24例,年龄36~,;感染情况:慢性支气管炎、阻塞性肺气肿并感染19例,液气胸并感染12例,肺炎12例,支气管扩张并感染6例,支气管哮喘并感染5例,胆石症并感染5例,眼部感染3例。除感染外,本组患者伴随其他基础疾病,其中,肺源性心脏病15例,2型糖尿病11例,高血压10例,慢性乙型肝炎10例,冠心病6例,结核性胸膜炎4例,脑梗死3例,前列腺增生症3例。

菌株分离与鉴定方法将脓液或痰标本分别接种于血平板(伊红美蓝平板),37℃培养箱培养18~24h,选择革兰阴性杆菌做鉴定。菌株鉴定:采用法国生物-梅里埃公司细菌鉴定仪。