毛酸浆浆果的化学成分分析.docx

Studies on Chemical Constituents from Berries of
Physalis pubescens L. Abstract
Physalis pubeacens L. has long been a minor fruit of China and has also been grown in America. The fruit of the Physalis Genus was also extensively used as herb medicine, and had the effects of detoxification and anti-inflammation in traditional Chinese medicine. the extract of fruits of the Physalis Genus had been reported to have potent antioxidant, anti-inflammatory, and cytotoxic activities. Previous studies on constituents from the Physalis genus led to the isolation of pounds such as triterpenoids, flavones, alkaloids and steroids.
During the course of our investigation for bioactive agents from the EtOH extract of calyxs of Physalis pubeacens L., pounds were obtained by using silica gel column chromatography, Sephadex LH-20 chromatography, MPLC, and Semi-HPLC, and structures of pounds were elucidated through spectroscopic analysis (NMR, MS and IR ). Their structures were identified to be 3, 7, 3'-trimethylquercetin (SG-1), kaempferol (SG-2), chrysoeriol (SG-3), quercetin-3-O-β-D-glucopyranoside (SG-4), arjunolic acid (SG-5), pulsatilla saponin A (SG-6), pulsatilla saponin D (SG-7), blumenolA (SG-8), caffeic acid (SG-9), 1-O-caffeoyl-β-D-glucopyranoside (SG-10), syringic acid β-D-glucopyranosyl ester (SG-11),5-O-caffeoyl quinic acid butyl ester (SG-12), 1-p-coumaroyl-β-D-glucopyranoside(SG-13), Calceolarioside A (SG-14),4-hydroxyl-3-methoxyl-benzoicacid(SG-15),1-O-p-feruloyl-β-D-glucopyranoside (SG-16), N-trans-p- hylferolamine (SG-17), neo-olivil (SG-18), medioresinol (SG-19), pinoresinol (SG-20), sucrose (SG-21), uridine (SG-22), adenosine
(SG-23), northrachelogenin (SG-24), β-sitosterol (SG-25), daucosterol (SG-26)。Among
them, SG-5~SG-8,SG-10,SG-11,SG-13~SG-24 were isolated from this genus for the first time. Compounds SG-3,SG-4 and SG-12 were obtained from this plant for the first time.
The antibacterial, antioxidation and antitumor activitis pounds and extract
Abstract