VEGF在子宫内膜异位症中的表达及其意义.doc

VEGF在子宫内膜异位症中的表达及其意义
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【摘要】目的观察血管内皮生长因子(VEGF)在子宫内膜异位症(EMS)中的表达并探讨其在EMS发病机制中的作用。方法利用免疫组化法检测VEGF在30例EMS的异位内膜及在位内膜组织、30例正常子宫内膜组织中的表达。结果 VEGF在异位内膜的表达显著高于在位内膜和正常子宫内膜()。VEGF在EMS在位内膜的表达显著高于正常子宫内膜()。结论 VEGF在EMS的发生、发展中起重要作用。
【关键词】血管内皮生长因子;子宫内膜异位症;免疫组织化学;表达
ABSTRACT:Objective To observe the expression of vascular endothelial growth factor (VEGF) in endometriosis,and to explore its possible role in the pathogenesis of endometriosis. Methods The expression of VEGF in 30 normal endometrium,30 ectopic endometrium and eutopic endometrium were detected by immunohistochemistry,and the data was analyzed with statistical software. Results The expression level of VEGF in the ectopic endometriotic tissues was significantly higher than those in the eutopic endometrium and nomal endometrium (),and the expression level of VEGF in the eutopic endometrium was significantly higher than that in nomal endometrium (). Conclusions VEGF may contribute to the pathogenesis of endometriosis.
KEY WORDS:Vascular endothelial growth factor;Endometriosis;Immunohistochemistry;Expression
子宫内膜异位症(EMS)发病机制涉及到多基因遗传、环境因素、免疫异常、血管生成异常及内分泌异常等多个环节。种植灶子宫内膜的快速生长需要大量的新生血管,血管内皮生长因子(VEGF)是血管内皮细胞的有丝分裂原和成形素,并对内皮细胞有趋化作用。在月经周期中VEGF参与子宫内膜的修复,具有很强的促血管形成能力。本研究采用免疫组化技术检测了VEGF在EMS异位内膜、在位内膜和正常子宫内膜中的表达,以了解其在EMS发病机制中所起的作用。
1 资料与方法
一般资料
30例EMS异位内膜标本取自武