卡维地洛治疗扩张型心肌病心力衰竭的疗效观察.pdf.pdf

现代医药卫生2008年24卷第8期1137卡维地洛治疗扩张型心肌病心力衰竭的疗效观察毕平。朱耀辉。刘开春()【摘要】目的:探讨卡维地洛对扩张型心肌病(DCM)心力衰竭(CHF)的临床疗效。方法:60例DCM并CHF患者在利尿剂、洋地黄、ACEI及硝酸盐制剂治疗的基础上,随机分为卡维地洛治疗组及常规治疗组(每组30例)。治疗前及4个月用超声心动图测左室缩短分数(FS),射血分数(EF)、左室舒张末内径(LVDD)、室间隔厚度(IVS)和左室后壁厚度(LVPW)。结果:治疗4月后,两组心功能改善。卡维地洛LVDD[(+)与(±)mm,P<]、EF[(±)与(±6,4)%,P<】、D门r【()与(±),P<。结论:卡维地洛能显著改善DCM心功能及心肌重构。【关键词】扩张型心肌病;心力衰竭;充血性;肾上腺素能B一受体阻制剂文章编号:1009—5519(2008)08—1137—02中图分类号:R5文献标识码:AObservationoftheeffectofcarvedilolincongestiveheartfailureinpatientswithdilatedcardiomyopathyBIPg,ZHUYao—hui,LIUKai—chun(DepartmentofInternalMedwineII,PeopleHospitalofYunyang,Chongqing404500,China)【Abstract]Objective:Toinvestigatetheclinicaleffectofcarvedilolinthetreatmentofcongestiveheartfailure(CHF)inpatien~tIldilatedcardiomyopathy(DCM).Methods:60DCMpatien~tIlCHFwererandomlydividedintocarvedilolgroupandcontrolgrouponthebasisofdigitalis,diuretic,ACEIandnitro-reatment,~actionshortening(FS),leftejec—tion~action(EF),strokvolume(SV),leftventriculardiastolicdimension(LVDD),interventricularseptum(IVS)andleftventricularpos—tedorwall(LVPW):4monthsaftertreatment,thecardiacfuntioninbothgroupsimprovedmarkedly,paredwithtIlatincontrolgroup,suchasLVDD(±±,P<),EF(±±,P<),andD/