The Organic Chemistry of Drug Synthesis Vol 3 (Lednicer, Wiley, 1988).pdf

ANIC CHEMISTRY
OF DRUG SYNTHESIS
VOLUME 3
DANIEL LEDNICER
Analytical Bio-Chemistry Laboratories, Inc.
Columbia, Missouri
LESTER A. MITSCHER
The University of Kansas School of Pharmacy
Department of Medicinal Chemistry
Lawrence, Kansas
A WILEY-INTERSCIENCE PUBLICATION
JOHN WILEY AND SONS
New York • Chlchester • Brisbane * Toronto • Singapore
Copyright © 1984 by John Wiley & Sons, Inc.
All rights reserved. Published simultaneously in Canada.
Reproduction or translation of any part of this work
beyond that permitted by Section 107 or 108 of the
1976 United States Copyright Act without the permission
of the copyright owner is unlawful. Requests for
permission or further information should be addressed to
the Permissions Department, John Wiley & Sons, Inc.
Library of Congress Cataloging In Publication Data:
(Revised for volume 3)
Lednicer, Daniel, 1929-
anic chemistry of drug synthesis.
"A Wiley-lnterscience publication."
Includes bibliographical references and index.
1. Chemistry, Pharmaceutical. 2. Drugs. 3. Chemistry,
Organic—Synthesis. I. Mitscher, Lester A., joint
author. II. Title. [DNLM 1. Chemistry, Organic.
2. Chemistry, Pharmaceutical. 3. Drugs—Chemical
synthesis. QV 744 L473o 1977]
615M9 76-28387
ISBN 0-471-09250-9 (v. 3)
Printed in the United States of America
10 907654321
With great pleasure we dedicate this book, too, to our wives,
Beryle and Betty.
The great tragedy of Science is the slaying of a
beautiful hypothesis by an ugly fact.
Thomas H. Huxley, "Biogenesis and Abiogenisis"
Preface
Ihe first volume in this series represented the launching of a
trial balloon on the part of the authors. In the first place,
wo were not entirely convinced that contemporary medicinal
(hemistry could in fact anized coherently on the basis of
organic chemistry. If, however, one granted that this might be
done, we were not at all certain that the exercise would engage
Ihe interest of other