The Organic Chemistry Of Drug Synthesis (Lednicer & Mitscher) Vol 4.pdf

ANIC CHEMISTRY
OF DRUG SYNTHESIS
VOLUME 4
DANIEL LEDNICER
National Cancer Institute
Bethesda, Maryland
LESTER A. MITSCHER
Department of Medicinal Chemistry
The University of Kansas
Lawrence, Kansas
with
GUNDA I.
Department of Medicinal Chemistry
The University of Kansas
Lawrence, Kansas
A Wiley-Interscience Publication
John Wiley & Sons, Inc.
New York / Chichester / Brisbane / Toronto / Singapore
Copyright © 1990 by John Wiley & Sons, Inc.
All rights reserved. Published simultaneously in Canada.
Reproduction or translation of any part of this work
beyond that permitted by Section 107 or 108 of the
1976 United States Copyright Act without the permission
of the copyright owner is unlawful. Requests for
permission or further information should be addressed to
the Permissions Department, John Wiley & Sons, Inc.
Library of Congress Cataloging in Publication Data:
(Revised for volume 4)
Lednicer, Daniel, 1929-
anic chemistry of drug synthesis.
"A Wiley-Interscience publication."
Includes bibliographical references and Index.
1. Chemistry, Pharmaceutical. 2. Drugs. 3. Chemistry,
Organic-Synthesis. I. Mitscher, Lester A., joint
author. II. Title. [DNLM 1. Chemistry, Organic.
2. Chemistry, Pharmaceutical. 3. Drugs-Chemical
synthesis. QV 744 L473o 1977]
615M9 76-28387
ISBN 0-471-85548-0(v. 4)
Printed in the United States of America
10 987654321
We dedicate this book to Beryle and Betty who continue to support us in every imaginable way
and to the memory of Katrina Mitscher-Chapman (1958-1987) who was looking forward with her
customary enthusiasm to helping us prepare the manuscript.
I cannot tell how the truth may be;
I say the tale as 'twas said to me.
Sir Walter Scott, "The Lay of the Last Minstrel"
Preface
Over a decade and a half have flown by since we started on the preparation of the first volume in
this series. We did not at that time envisage a series at all but simply a book which filled what we