ChronicRenalInsufficiencyLuFumingDivisionofNephrology,HuashanHospital,ephropathychronicpyelonephritismulticystickidneysystemiclupusnephritis3PathogenesisMechanismassociatedwithexacerbationofrenalfunctionMechanismassociatedwithuremicsymptom4MechanismAssociatedWithExacerbationofRenalFunctionHyperfiltrationtheoryEffectofproteinuriaTrade-offhypothesisinacidosisDisturbanceoflipidmetabolismTubulointerstitialinjuryRenalhypoxia5MechanismAssociatedWithUremicSymptomUremictoxinsmalnutritiontrade-offhypothesisEndocrinedysfunction6ManifestationoftheUremicSyndromeGastrointestinalCardiovascularHematologicPulmonaryNeurologicDermatologicEndocrinologicophthalmic7GastrointestinalManifestationAnorexiaprogressingtonauseaandvomitingStomatitisandgingivitisParotitisPepticulcerdiathesisGastritis,hemotaxisDepressedlymphocytefunctionPlateletdysfunction10
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