酮基布洛芬课程设计.zip

目 录
1 产品概述 ··········································· 1
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2 工艺描述 ··········································· 2
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············································2
3 物料衡算 ··········································· 3
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4 能量衡算 ··········································· 8
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5 设备选型 ·········································· 13
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6 车间设计 ·········································· 21
7 污染处理 ·········································· 23
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··· 23
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8 岗位选派 ·········································· 25
参考文献 ············································26
附录：


1 产品概述
基本性质
酮基布诺芬的名称（英）：Ketoprofen 、商品名：欧露维、别名：苯酮苯丙酸；酮基布洛芬；优洛芬。
酮基布洛芬：白色结晶性粉末，无臭或几乎无臭。在甲醇中极易溶，在乙醇、丙酮或乙醚中易溶，在水中几乎不溶。熔点约93——96℃。为芳基烷酸类化合物。具有镇痛、消炎及解热作用。消炎作用较布洛芬为强，副作用小，毒性低，口服易自胃肠道吸收。1次给药后，～ 2小时可达血浆峰浓度，t1/～。在血中与血浆蛋白结合力极强。在24小时内自尿中的排出率为30%——90%，主要以葡萄糖醛酸结合物形式排出。用于类风湿性关节炎、风湿性关节炎、骨关节炎、关节强硬性脊椎炎及痛风等。
药物相互作用
饮酒和与其他非甾体类抗炎药同时使用，会增加肠胃道副作用，也有引起溃疡的危险性。
与阿司匹林或其他水杨酸类药物同用时，不能增加疗效，而胃肠道副作用及出血倾向发生率增高。
与抗凝血药同用，增加出血危险。
本品可增强抗糖尿病药物作用；降低抗高血压药物的降压作用；与皮质激素类同用，可明显地减缓炎症症状。
不宜与甲氨蝶呤同用，以防中毒。
与丙磺舒和维拉帕米、硝苯地平同用时，要注意降低剂量；与地高辛同用时，注意调整地高辛用量。
2 工艺描述


本次设计内容中所采用的工艺是以苄醛为原料，与高锰酸钾在碱性苯溶液中氧化反应，再经中和提取、洗涤分层、脱色等一系列工序制得产品。本路线工序较短，对反应条件，反应设备的要求也不高，而且生产成本也较低，适合于工业大规模生产。产品经过回收，精制等多道工序，最终得到较为纯净的产品。