飞行时间质谱综述.pdf

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RAPID COMMUNICATIONe quadrupoles and double-focusing mass spectrometers with TOF analysers. Ion-traps have also
been coupled with TOF instruments. © 1997 by John Wiley & Sons, Ltd.
Received 31 October 1996; Revised 15 April 1997; Accepted 25 April 1997
Rapid. Commun. Mass Spectrom. 11, 951–962 (1997)
No. of Figures: 17 No. of Tables: 0 No. of Refs: 41
The technique of time-of-flight mass spectrometry packets have, until recently, placed considerable con-
(TOFMS) has returned as a prominent mass analysis straints on the sensitivity of the TOF mass analyser. The
method. TOFMS can be advantageous compared to need to form discrete packets of ions has provided a
scanning technologies because of its ‘unlimited’ mass challenge in the coupling of continuous ion sources to
range, high speed and the potential for high duty factors TOFMS.
(% of ions formed that are detected). Two important The development of the ion mirror (or reflectron)3
causes for the renewed activity in TOFMS can be and the orthogonal acceleration time-of-flight mass
identified: (i) The development of and need for new spectrometer (oa-TOFMS)4–6 have been key stages in
ionization methods capable of generating ions of the revival of TOFMS.
structural significance from high molecular weight
materials. In particular, developments in ion sources for
molecular biology provide a strong driving force for FACTORS CONTRIBUTING TO TOFMS
TOFMS. Matrix-assisted laser desorption/ionization RENAISSANCE
(MALDI)1 and electrospray ionization (ESI)2 have
been prominent in this regard. (ii) The facilitating The simplicity of the physical principles of TOFMS
technologies for TOFMS have advanced dramatically underpin its current successes. The mass–velocity rela-
during the past decade. These include affordable pulsed tionship