A型肉毒毒素治疗玫瑰痤疮的研究进展.pdf

中国皮肤性病学杂志
The Chinese Journal of Dermatovenereology
ISSN 1001-7089,CN 61-1197/R
eking Union Medical College Hospital, Chinese Academy of
Medical Sciences and Peking Union Medical College, Beijing 100730, China ）
[Corresponding author] SUN Qiuning, E-mail: ******@
【Abstract】Rosacea is a chronic inflammatory disease mediated by a variety of mechanisms.
Currently, the efficacy of treatments for intractable flushing and erythema caused by rosacea is
limited. Botulinum toxin A (BTX-A) can reduce inflammatory factors and alleviate the continuous
dilation of vessels by inhibiting mast cells degranulation and blocking the release of acetylcholine
and neuropeptide. Therefore, BTX-A can relieve the symptoms of facial flushing, which has the
potential to treat rosacea. The efficacy and safety of BTX-A in the treatment of rosacea have been
preliminarily confirmed by relevant studies, so BTX-A may be a new type of effective therapy for
the treatment of rosacea.
【Key words】 Botulinum toxin A(BTX-A); Rosacea; Neuropeptide; Substance P; Laser

玫瑰痤疮是一种由多种机制介导的慢性炎症性疾病，常表现为面部阵发性潮红、毛细血
管扩张、红斑、丘疹、脓疱等，少部分患者也可出现赘生物及眼部损害[1]。目前玫瑰痤疮的
治疗方法主要包括外用甲硝唑、口服抗生素及激光治疗等，但针对持续性面部潮红的治疗方