4 氯 6 甲氧基 7 3 4 吗啉基 丙氧基 喹啉的合成.pdf

4_氯_6_甲氧基_7_3_4_吗啉基_丙氧基_喹啉的合成化学试剂
Chemical Reagents
ISSN 0258-3283,CN 11-2135/TQ

1-溴-3-氯丙烷发生醚化反应，然后再与吗啉发生亲
核取代反应，且将醚化及亲核取代两步反应合为一锅反应。再经铁粉还原、与米氏酸缩合、高温环合、氯
代共 6 步反应制得目标化合物，反应总收率为 %。所有化合物结构经 MS 和 1HNMR 进行确证。该路线
步骤简洁、耗时短、操作简单，收率较高。
关键词：4-氯-6-甲氧基-7-[3-(4-吗啉基)丙氧基]喹啉；Foretinib；c-met 激酶抑制剂；抗肿瘤；合成
中图分类号：O625 文献标识码：A

Synthesis of 4-Chloro-6-methoxy-7-(3-(4-morpholine)propoxy)quinoline Zhao Pei-pei, Wang
Gang, Zhang Fan *(Jinzhou Medical University, Liaoning Jinzhou, 121001, China), Huaxue Shiji.
Abstract: A new method for the synthesis of
4-chloro-6-methoxy-7-(3-(4-morpholine)propoxy)quinoline, which was an important
intermediate of Foretinib a c-Met kinase inhibitors, was provided.
4-Chloro-6-methoxy-7-(3-(4-morpholine)propoxy)quinoline was synthesized from
2-methoxy-5-nitrophenol via six-step reaction: etherification reaction with