狼疮肾炎复发.docx

Recurrent Nephrotic Syndrome After Renal Transplant in Children.
Saeed B, Mazloum H.
Exp Clin Transplant. 2016 Dec;14( donor grafts are associated with increased incidence of recurrence of nephrotic syndrome
Possible role for glomerular-derived angiotensinogen in nephrotic syndrome.
Yamazaki M, Fukusumi Y, Kayaba M, Kitazawa Y, Takamura S, Narita I, Kawachi H.
J Renin Angiotensin Aldosterone Syst. 2016 Dec 8;17(4). pii: 1470320316681223.
PMID:27932705
Abstract
BACKGROUND AND OBJECTIVE:
Renin-angiotensin system (RAS) inhibitors reduce glomerular injury and proteinuria, indicating that angiotensin II (Ang II) is involved in glomerular diseases. Although the local RAS is reported to play an essential role in maintaining local tissue functions, the role of the local RAS in regulating glomerular function is not well evaluated. In this study, we analyzed the glomerular expression of RAS components in nephrotic models and the effect of Ang II receptor blockers (ARB) on the expression of angiotensinogen (AGT).
METHODS:
The levels of glomerular expression of RAS components were analyzed in two nephrotic models: anti-nephrin antibody-induced nephropathy and PAN肾病嘌呤霉素氨基核苷 nephropathy, a mimic of human minimal change nephrotic syndrome. The effect of the ARB irbesartan 厄贝沙坦on the expression of AGT in the nephrotic model was analyzed.
RESULTS:
Glomerular expression of AGT and t