2 氟哌噻吨美利曲辛联合心理干预在慢性阻塞性肺疾病伴焦虑抑郁患者中的应用效果 Application effect of Flupenthixol Melitracen combined with psychological intgen therapy, eliminating phlegm and symptomatic and supportive treatment. On basis of control group, the observation group was added with Flupenthixol Melitracen and psychological intervention. Both groups were taken 2 weeks as a course. The clinical effects of the two groups were observed, the scores of Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD), and the scores of chronic obstructive pulmonary disease assessment test (CAT) of the two groups before and after treatment were compared. Results The total effective rate of observation group was significantly higher than that of control group, the difference was statistically significant (P 7~17分;中度焦虑/抑郁:总分>17~24分;重度焦虑/抑郁:总分>24分[10]。 2 慢性堵塞性肺疾病评估测试(COPD assessment test,CAT)问卷包含8个问题,每个问题均分为0~5分,总分0~40分。CAT分4级,略微影响:0~10分;中度影响:11~20分;严峻影响:21~30分;特殊严峻影响:30~40分[11-12]。分值越高,生活质量越差。 统计学方法 接受统计软件SPSS ,正态分布的计量资料以均数±标准差(x±s)表示,两组间比较接受t检验;计数资料以率表示,接受χ2检验。以P )。两组治疗后HAMA和HAMD评分均较治疗前显著下降,差异均有统计学意义(P ),观看组治疗后CAT评分较治疗前显著降低,且显著低于对比组,差异均有统计学意义(P < )。 3 讨论 4 COPD患者临床主要表现为气促、呼吸困难,焦虑抑郁会加重COPD患者的上述症状,而加重的临床症状又会反过来加深患者的焦虑抑郁情绪,两者相互影响,形成恶性循环[13]。焦虑抑郁情绪一方面会影响下丘脑-垂体-肾上腺轴的功能,降低人体免疫力,增加人体感染疾病的概率;另一方面会降低患者战胜疾病的信心,影响治疗依从性,不利于疾病的预后[14]。同时,研