注射用盐酸头孢噻呋混悬乳剂制备及品质考察.pdf

注射用盐酸头孢噻呋混悬乳剂制备及品质考察.pdfj201120(7)3236
￡口癦￡“,‘袯趎—训秄口￡ Sii .
注射用盐酸头孢噻呋混悬乳剂制备及品质考察
赵蓓,欧阳五庆,刘伟,商育锦
鞅迸┝挚萍即笱Ф镆窖г海挛餮盍
摘要:通过预试验确定盐酸头孢噻呋混悬乳剂的各组成成分,并确定其使用范围。采用正交试验对混悬乳
剂的配方进行优化,并通过各指标对混悬乳剂进行品质考察。最终得到其最优配方为注射用大豆油、乳化剂、
增稠剂和抗氧化剂质量分数分别为ァ%、⑸溆盟又了枇俊W罴汛Ψ降酿ざ任 s
(O4所需的时间ㄕ胄粤己茫蟛糠至>段狾.~豰,且粒径不大于雖,盐酸头
10036
关键词:盐酸头孢噻呋;混悬乳剂;制备;品质考察
中图分类号:. A文章编号:—一一
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专用于动物的第锋呔乩嗫股乜赸。盐酸成人力财力的浪费,而且使动物产生很大的应激
头孢噻呋抗菌活力强、抗菌谱广,而且还具有安全反应。研制其长效制剂可以有效解决上述问题,
性高和残留量低的特点,对治疗大肠菌属引起的减少用药次数、降低成本,从而对养殖业的发展起
水牛乳腺炎效果良好Ⅲ。目前,注射用头孢噻呋[(SuspoemuIsions)
钠粉针剂及盐酸头孢噻呋混悬注射液已研制成称悬乳状液、悬浮乳液,是由不溶予水的固体药