视神经脊髓炎谱系疾病神经眼科表现.pdf

2014 10 14 10 Chin J Contemp Neurol Neurosurg, October 2014, Vol. 14, No. 10
中国现代神经疾病杂志年月第卷第期· 845 ·
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专题综述
视神经脊髓炎谱系疾病神经眼科表现
张晓君许贤豪
【摘要】视神经脊髓炎谱系疾病包括经典视神经脊髓炎、视神经脊髓型多发性硬化、视神经脊髓炎
限定型,以及伴系统性自身免疫性疾病或视神经脊髓炎特征性影像学表现的孤立性视神经炎或脊髓
炎。其特征性神经眼科表现包括双侧同时或相继发生的视神经炎、视盘水肿和盘周渗出,视功能恢复
4 MRI
差,对糖皮质激素有较好的反应性和依赖性。这些临床特征与水通道蛋白抗体检测和头部检查
相结合,可为视神经脊髓炎谱系疾病与多发性硬化的早期鉴别诊断提供帮助。视神经脊髓炎谱系疾病
可能出现某些特征性眼球运动异常,尚待进一步研究。
【关键词】视神经脊髓炎; 自身免疫疾病; 眼科学; 综述
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Neuro ophthalmic manifestation of neuromyelitis optica spectrum disorders
ZHANG Xiao⁃jun1, XU Xian⁃hao2
1Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
2Department of Neurology, Beijing Hospital, Beijing 100730, China
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Corresponding author: ZHANG Xiao jun (Email: zxjsusan1@)
Neuromyelitis optica spectrum disorders (NMOSDs) include classic neuromyelitis optica
【Abstract】
(NMO), opticospinal multiple sclerosis (OSMS), limited form of NMO and isolated optic neuritis or myelitis
panied by either systemic autoimmune diseases or typical MRI findings of NMO. mon neuro⁃
ophthalmic features of NMOSDs include simultaneous or consecutive bilateral optic neuritis, more
commonly seen optic disk edema and surrounding exudate, poor visual recovery, steroid responsiveness and
dependency. Combined with serum aquaporin 4 (AQP4) antibody and brain MRI examination, these clinical