顶空气相色谱法测定利奈唑胺中残留有机溶剂.doc

顶空气相色谱法测定利奈唑胺中残留有机溶剂
魏欣
(江苏省肿瘤医院药剂科江苏南京 210000)
【摘要】采用顶空气相色谱法测定利奈唑胺中的残留有机溶剂。载气为氮气,检测器为FID,色谱柱为DB-624毛细管柱,柱温为40℃,检测器温度为250℃,进样口温度为180℃,测定利奈唑胺中甲醇、乙醇、异丙醇、二氯甲烷、乙酸乙酯、四氢呋喃和甲苯的残留量。结果显示7种溶剂达到完全分离,在考察的质量浓度范围内具有良好的线性关系,,%~%。用所建立的分析方法测定利奈唑胺中的残留有机溶剂,结果准确、可靠。
【关键词】利奈唑胺;顶空气相色谱法;残留有机溶剂
【中图分类号】 【文献标识码】A 【文章编号】2095-1752(2016)23-0028-03
Headspace gas chromatography determination of anic solvents in rina thiazole amineWei Xin.
The Tumor Hospital of Jiangsu Province, Jiangsu Province, Nanjing 210000, China
【Abstract】By headspace gas chromatography method for determination of anic solvents in rina thiazole amine. Carrier gas is nitrogen, to FID detector, chromatographic column for the DB - 624 capillary column, column temperature of 40℃,detector temperature is 250 ℃, sample temperature is 180 ℃, the determination of rina thiazole amine in methanol, ethanol, isopropanol, dichloromethane, ethyl acetate, tetrahydrofuran and toluene residue. , according to the results of 7 kinds of solvent to plete separation, within the scope of the mass concentration has good linear relation, r achieves , the average recovery was % ~ %. Using the established analysis method for
determination of anic solvents in rina thiazole amine, and the results are accurate and reliable.
【Key words】Rina thiazole amine; Headspace gas chromatography; The anic solvents