黄芩的调节性提取工艺研究.doc

黄芩的调节性提取工艺研究
徐晓英1 安睿2 王新宏2 张国明1
(1,上海市中药研究所,上海201203;2,上海市中医药大学,上海201203)
关键词:黄芩,黄芩苷,黄芩素,酶解
[摘要]目的:寻找一种能调节黄芩中的黄芩苷与黄芩素比例的提取方法。方法:利用黄芩药材中共存酶特性,应用正交设计法对提取工艺进行筛选,采用高效液相色谱法测定黄芩苷和黄芩素的含量作为评价指标。结果:控制酶解条件,可制备黄芩苷与黄芩素按预设要求的黄芩提取物。结论:本文为灵活提取黄芩提供了有益参考。
所属专业:中药和天然药物(中药现代分析及质量标准研究)
Studies on adjucted extraction of Scutellaria baicalensis
XU Xiao-ying, AN Rui, WANG Xin-hong, ZHANG Guo-ming
(Shanghai Institute of Chinese Materia Medica 201203, Shanghai University of TCM, Shanghai 201203)
Key words: Scutellaria baicalensis i; baicalin; baicalein; hydrolysis
ABSTRACT Object: To look for an extraction of Scutellaria baicalensis from which Baicalin and Baicalein can be extracted in a designed ratio. Methods: Utilizing the biological enzyme coexisted in the raw material of Scutellaria baicalensis, the extract which contains Baicalin and Baicalein in a certain ratio was obtained by a mildly enzymic hydrolysis of the Baicalin to Baicalein. Results: The ratio of the glycoside and its gene in the extract can be aimed by controlling the condition of enzymic : This article provide a useful reference to extract Scutellaria baicalensis flexibly.
黄芩为唇形科植物黄芩(Scutellaria baicalensis i )的根,来源于
唇形科植物黄芩、滇黄芩、粘毛黄芩和丽江黄芩的根,具清热燥湿、泻火解作者简介:徐晓英(1977~ ),女,汉族,上海市人,工程师,从事制剂及质量标准研究,E-mail:xxycherry@
毒、
凉血止血等功效[1]。黄芩主要成分为黄酮类、挥发油和氨基酸等。黄酮类以黄芩素(Baicalein)、黄芩苷(Baicalin)为主要成分,并含少量汉黄芩素(Wogonin)、汉