不同孕周与孕中期唐氏综合征筛查效率分析.docx

不同孕周与孕中期唐氏综合征筛查效率分析.docx不同孕周与孕中期唐氏综合征筛查效率分析新疆石河子大学医学院第一附属医院,832000)【摘要】目的:通过对新疆石河子地区各孕周孕妇唐氏综合症的风险状况分析,以期得到木地区筛查效率较高的孕周,为临床提供参考数据。方法用时间分辨法检测1331例孕中期15~20+6周母体三联血清标志物浓度,运用专业的产筛软件进行胎儿风险评估,对比不同孕周唐氏综合征高风险和患儿检出率。结果孕周与唐氏综合征筛查假阳率相关,>L孕周在16-18+6周的检击率最高,为100%,%。结论孕中期唐氏综合征筛查最佳孕周段为16-18+6周。关键词:孕中期;唐氏综合症筛查;孕周;假阳性率AnalysisoftheefficiencyofscreeningforDown'ordingtodifferentgestationalweeksHongLilYuWei2(TheFirstAffiliatedHospitalofXinjiangShiheziUniversityMedicalCollege,832000),[abstract]objective:ThroughtheanalysisoftheriskstatusofthepregnantwomenwithDownsyndromeinShiheziDistrictofXinjiang,getthehighscreeningefficiencyofthegestationalweek,:Timeresolutionmethodwasusedtodetectthematernalserumtriplebiomarkerconcentrationsof1331puerperaduringsecondtrimester15to20+:therateoffalsepositiveinscreeningforDown'ssyndromewasrelatedtogestationalage,andthedetectionrateofgestationalweekwasthehighestat8+6weeks,100%.%.Conclusions:theoptimalgestationalweekperiodofDown"ssyndromescreeninginthesecondtrimesterofpregnancyis16・18+:secondtrimesterofpregnancy;Downsyndromescreening;gestationalage;falsepositiverate唐氏综合征(Down'ssyndrome,DS)又称21三体综合征,是一种常见的染色体异常疾病,其病因为21号染色体上多了一条染色体所致,患者常表现为先天智力低下,面容特殊,发育迟缓等⑴,目前无有效的药物