MS法同时测定水产品中氯霉素、氟甲砜霉素及甲砜霉素残留量.doc

MS法同时测定水产品中氯霉素、氟甲砜霉素及甲砜霉素残留量MS法同时测定水产品中氯霉素、,.,2007GC/MS法同时测定水产品中氯霉素,氟甲砜霉素及甲砜霉素残留量冷凯良孙伟红王志杰王建华邢丽红.(中国水产科学研究院黄海水产研究所,青岛266071)(山东省出入境检验检疫局,青岛266002)(.中国海洋大学,青岛266003)摘要建立了气相色谱一负离子化学电离源质谱同时测定水产品中氯霉素(CAP),氟甲砜霉素(FF)和甲砜霉素(TAP),实现了氯霉素,甲砜霉素及氟甲砜霉素三甲基硅(TMS)衍生物的良好分离,检测模式采用选择离子检测(sIM),监测离子为:氯霉素(m/z376,378,466,468),氟甲砜霉素(m/z339,341,429,431)及甲砜霉素(m/z409,4l1,499,501),分别选择466,339,,有效地消除了基体效应的影响,,,,,,/,g/kg,/,g/—7075(2007)05—0095—05Simultaneousdeterminationofchloramphenicol,florfenicolandthiamphenicolresiduesinaquaticproductswithgaschromatography/massspectrometryLENGKai—liangSUNWei—hongWANGZhi—jieWANGJian—huaXINGLi—hong.(YellowSeaFisheriesResearchInstitute,ChineseAcademyofFisherySciences,Qingdao266071)(ShandongEntryExitInspectionandQuarantineBureau,Qingdao266002)(.OceanUniversityofChina,Qingdao266003)ABSTRACTAmethodusedforsimultaneousfenicol(FF)andthiamphenicol(TAP)residuesdeterminationofchloramphenicol(CAP),flor—inaquaticproductswasdevelopedbyusinggaschromatogramphy/massspectrometry(GC/MS),(SIM)wasadoptedasexaminationmode,withmonitoringionatm/z376,378,466and468forCAP,atm/z339,341,429and431forFF,atm/z409,411,499and501forTAP,andthequantitativeionsbeing466,339and409,re一农业部标准计划项目(2006—64—160)资助收稿日期:2006—12-28;接受日期:2007—03—16作者简介;冷凯良(1966一),男,高工,-mail:******@ysfri.,Tel:(0532)—~200ng/ml,,,withallcorrelationcoefficients>