新城疫病毒治疗中晚期恶性肿瘤临床观察.pdf

新城疫病毒治疗中晚期肝恶性肿瘤临床观察研究生姓名:指导教师:指导,J、组:专业名称:于显凤陶秀娟教授孙德宇副教授肿瘤学摘要背景与目的:新城疫病毒(NDV)属于副粘液病毒科,是一种家禽类病毒,已经证实新城疫病毒具有在感染肿瘤细胞后能抑制肿瘤细胞生长,加速肿瘤细胞调亡的作用,本研究旨在探讨新城疫病毒(NDV)在肝癌患者中的临床应用疗效。方法:选择经肝增强cT或病理学诊断为中晚期肝癌患者60例,分成治疗组和对照组,各30例,治疗组给予新城疫病毒(NDV)联合白介素一2治疗,对照组给予单纯白介素一2治疗,通过对照治疗组和对照组的疾病控制率(CR+PR+SD),疾病进展时间(TTP)、总生存期(0S)等,加以分析比较,从而得出结论。结果:治疗组疗效评价:CRO例,PR2例,SDl5例,PDl3例,客观有效率(ORR)7%,疾病控制率(DCR)57%,,(-16个月),%(1例);对照组疗效评价:对照组完全缓解0例,部分缓解0例,稳定9例,进展21例,客观有效率096,疾病控制率30%,,(-11个月),副反应发生率0%(0例)。治疗组疾病控制率优于对照组,经统计学分析,p<,有统计学差异。结论:新城疫病毒(NOV)治疗中晚期肝癌可缓解临床症状,一定程度上提高病人的无病生存期,但尚不能证实其可提高肝癌患者总生存期。关键词:肝癌新城疫病毒晚期TheclinicalobservationoftheadvancedlivercancertreatedbyNewcastlediseasevirusMasterdegreecandidate:XianfengYuSupervisor:ProfessorXiujuanTaoVice·supervisor:AssociateProfessorDeyuSunMajor:oncologyAbstractBackground:Newcastlediseasevires(NOV)belongingtoParamyxivirinae,,invitrotest,NDVCallsuppressthetumourcelltogrow,inducedthetunlourcelltoapoptosis,:60patientswhichhadbeendiagnosedtotheadvancedlivercancerwasselectedbyenhancementCTorthepathologydiagnosis,dividedintothetreatmentgroupandthecontrolgroup,(NDv)binedly,andthecontrolgroupWastherapiedbyIL-2treatmentspurily,paredtreatmentgroupandcontrolgroup’Schild—pu曲graduation,diseaseinverseamplificationfactor(CR+PR+SD),Time-To-Progression(”曙),Overallsurvivaltime(OS)andthesidereactionrateandSOon,:Evaluationoftreatmentgroup:CRis0patient,PRis2patients,SDis15patients,PDis13patients,ORRis7%,DCRis57%,,r],(-16months),%(1patient);Evaluationofcontrolgroup:CRis0patient,PRis0patient,SDis9patients,PDis2patients,ORRis0%,DCRis30%,(—1months),SideeffectrateisO%(0patient