伊贝沙坦对高血压病患者血浆胰岛素水平的影响重点.doc

伊贝沙坦对高血压病患者血浆胰岛素水平的影响重点.doc伊贝沙坦对高血压病患者血浆胰岛素水平的影响
【关键词】 伊贝沙
【摘要】 目的 观察伊贝沙坦对高血压病(EH患者胰岛素敏感性的影响。方法
42例高血压病患者根据血压高低分别给予伊贝沙坦 150〜300mg 口服每天1次。治疗前及治疗
8周后，分别测定空腹血浆血糖( FPG及空腹血浆胰岛素(FPI)，计算胰岛素敏感指数
(ISI )，并与40例性别、年龄、体重指数相同的健康者比较。结果 两组FPG均正常，差异无
显著性；EH组治疗前FPI显著升高( )，ISI显著下降( )。伊贝沙坦治疗 8周
后，FPI显著下降( )，ISI显著增高( )。结论 高血压病患者存在高胰岛素血 症，伊贝沙坦在稳定降压的同时能不同程度地改善高胰岛素血症。
关键词伊贝沙坦高血压病胰岛素
The effect of Aprovel on the plasma in suli n level in the patie nts with
hyperte nsion
Yu Zeqi ， Su Weiqing ， Li Shuyu ， et al.
The People ' s Hos pital of Lianjiang ， Guangdong524400.
【Abstract 】 Objective To study the effect of Aprovel on the insulin
sen sitivity in patie nts with hyperte nsion. Methods 42patie nts were give n150 〜300mg
once a day accord ing their blood fasti ng plasma glucose ( FPG and
fasting plasma insulin ( FPI) were measured ， and calculated the insulin sensitive
index (ISI ) before and8weeks after results were compared with40health
people who had the similar sex ， age and weight The FPG of two groups
was no rmal and without sig nifica nt differe FPI was in creased ( P< ) and
ISI was decreased ( P< ) markedly before therapy in the hypertensive
FPI was decrased ( P< ) and ISI was inereased ( P< ) markedly after therapy of on clusio n The hyperte nsive patie nts have hyperi nsuli can imp