放射性肺损伤防护的研究进展.pdf

肿瘤 2012 年 5 月第 32 卷第 5 期 TUMOR Vol. 32, May 2012
DOI: .1000-
Copyright© 2012 by TUMOR
综述·Review
放射性肺损伤防护的研究进展
毛艳,刘文其
,
广西医科大学第一附属医院放疗科南宁 500021
[ 摘要] 放射性肺损伤是胸部肿瘤放疗后的常见并发症,主要表现为早期的放射性肺炎和晚期的放射性肺纤维化,
与肺的受照体积和受照剂量密切相关,与多种细胞因子的表达及信号转导也密切有关。本文对放射性肺损伤防护
的最新研究进展进行了综述。
[ 关键词] 辐射性肺损伤;辐射防护;中草药;综述
[中图分类号] [文献标志码] A [文章编号] 1000-7431 (2012) 05-0389-06
The progress in the research on the prevention and protection of radiation-induced lung injury
MAO Yan, LIU Wen-qi
Department of Radiation Oncology, First Affiliated Hospital, Guangxi Medical University, Nanning 500021, China
[ABSTRACT] Radiation-induced lung injury is plication closely related to radiation
volume and radiation dose of the lung in chest radiation, including early radiation pneumonia and late
pulmonary fibrosis. Radiation-induced lung injury is also closely associated with the expressions of
multiple cytokines and signal transduction. This paper summarizes the advances in the research of
prevention and protection of the radiation-induced lung injury in recent years.
[KEY WORDS] Radiation-induced lung injury; Radiation protection; Drugs, Chinese herbal; Review
[TUMOR, 2012, 32 (05): 389-394]
放射性肺损伤是胸部肿瘤放疗后的常见并发症,制约疗急性放射性肺损伤,而对晚期的放射性肺纤维化,至今
了放射剂量的提高,可导致肿瘤局部控制率的降低甚至是仍无有效的预防和治疗措施。因此,放射性肺损伤的治疗
放疗的中断;同时,影响患者的生活质量,甚至可致相关关键在于有效的防护。
性死亡。不同研究报道的胸部肿瘤放疗后放射性肺损伤的
发生率各