注射用炎琥宁与甲硝唑注射液的配伍稳定性考察.doc

注射用炎琥宁与甲硝唑注射液的配伍稳定性考察
【摘要】目的考察注射用炎琥宁与甲硝唑注射液的配伍稳定性。方法在室温(25℃)下,采用紫外分光光度法测定注射用炎琥宁与甲硝唑注射液的含量,8 h内各时间段考察配伍液的含量、外观性状、紫外光谱、pH值及微粒数变化。结果配伍液外观、pH值及含量均无明显变化。结论注射用炎琥宁与甲硝唑注射液配伍后在室温下8 h内可使用。
【关键词】炎琥宁甲硝唑配伍稳定性
Abstract:ObjectiveTo study the stability of the mixture of Injection NatriiKaliiDehydroandrographolidie inate and Metronidazole injection. MethodsThe contents were determined by UV spectrophotometry after mixing of Injection NatriiKaliiDehydroandrographo-lidie inate with Metronidazole injection under the room temperature within 8 hours, and the appearance,pH values,UV spectrum, numbers of particles of the solution were observed. ResultsNo significant differences were found in terms of the appearance,pH value and the contents of the mixed solution. ConclusionThe mixture of Injection NatriiKaliiDehydroandrographolidie inate with Metronidazole injection can be used under room temperature within 8 hours of mixing.
Key words:Injectionatriikalii; Dehydroandrographolidie inate; Metronidazole; Compatibility; Stability
炎琥宁是用传统中药穿心莲提取物穿心莲内酯与琥珀酸酐酯化,再经
成盐而制得,是穿心莲内酯的新型衍生物,化学名称为14-脱羟-11,12-二脱氢穿心莲内酯-3,19-二琥珀酸半酯钾钠盐-水合物。炎琥宁有良好抗病毒、抗炎、解热作用,广泛用于病毒性肺炎和病毒性上呼吸道感染。甲硝唑是目前临床应用广泛的厌氧菌感染的药品,两者能否在同一输液中配伍使用未见报道[1,2],为配合临床合理用药,本实验参照临床用药浓度,对注射用炎琥宁与甲硝唑注射液的配伍稳定性进行了考察,旨在为临床合理用药提供。
1 仪器与试剂
仪器
UV-2100型紫外分光光度计(日本岛津);pHs-3C型酸度计(上海华侨仪表厂);ZWF-J6型注射液微粒分析仪(天河医疗仪器有限公司);AEU-200天平(日本岛津)。
试剂
注射用炎琥宁(重庆药友药