肝性脑病治疗进展.pdf

218 J Clini 2011,,
肝性脑病治疗进展
徐大海,张楠,高金莹,吴扬
(吉林大学第一医院急诊科, 长春 130021)
摘要: 肝性脑病(HE)是严重肝病常见的并发症和死亡原因。由于其发病机制不明确,目前仍以综合治疗为主。近年来
在HE的治疗方面取得了很大进展,在传统治疗方法基础上,益生菌、锌制剂、抗幽门螺杆菌、血液净化、肝移植和胎儿肝
干细胞移植等技术亦用于HE治疗。本文就HE治疗进展进行综述。
关键词: 肝性脑病;血浆肾换;血液灌注;肝移植;干细胞移植
中图分类号: 文献标识码: A 文章编号: 1001-5256(2011)02-0218-04
The therapeutic development of hepatic encephalopathy
XU Da-hai, ZHANG nan, GAO Jin-ying, et al. (Department of Emergency, the First Hospital of Jilin University, Changchun 130021,
China)
Abstract: Hepatic encephalopathy(HE) is plication mon cause of death with severe liver diseases. As
the pathogenesis of HE is unclear, current treatment is mainly focused on prehensive treatment. In recent years, there has
been a great improvement in the treatment of HE. In addition to the conventional treatment, new therapy including probiotics, zinc
preparation, blood purification, anti-helicobacter pylori, liver transplantation and fetal liver stem cell transplantation are used to treat
HE. This article reviews the therapeutic development of HE.
Key words: hepatic encephalopathy; plasma exchange; hemoperfusion; liver transplantation; stem cell transplantation
肝性脑病(hepatic encephalopathy,HE)是由板,积极治疗消化道出血、纠正休克、缺氧和
严重肝病引起的,以代谢紊乱为基础的中枢神经肾前性尿毒症。
系统功能障碍的综合征,临床表现为意识障碍和 避免大量排钾利尿和放腹水利尿过量或大
行为失常,是严重肝病常见的并发症和死亡原量放腹水可引起HE,此时应停用利尿剂及停放
因。HE发病机制目前尚无明确的发病