盐酸酚苄明片 1.doc

盐酸酚苄明片_1盐酸酚苄明片_1
Dibenzyline Tablets
Manufacturer: WellSpring
DESCRIPTION
Each Dibenzyline tablet is imprinted WPC 001 and 10 mg and contains phenoxybenzamine
hydrochloride, 10 mg. Inactive ingredients consist of benzyl alcohol, cetylpyridinium chloride, D&C Red No. 33, FD&C Red No. 3, FD&C Yellow No. 6, gelatin, lactose, sodium lauryl sulfate and trace amounts of other inactive ingredients.
Dibenzyline
Phenoxybenzamine hydrochloride is a colorless, crystalline powder with a molecular weight of which melts between 136° and 141°C. It is soluble in water, alcohol and chloroform; insoluble in ether.
CLINICAL PHARMACOLOGY
Dibenzyline (phenoxybenzamine hydrochloride) is a long-acting, adrenergic, alpha -receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect . It has no effect on the parasympathetic system.
Twenty to 30 percent of orally administered phenoxybenzamine appears
to be absorbed in the active form. 1
The half-life of orally administered phenoxybenzamine hydrochloride is not known; however, the half-life of intravenously administered drug is approximately 24 hours. Demonstrable effects with intravenous administration persist for at least 3 to 4 days, and the effects of daily administration are