托烷司琼预防含顺铂化疗药物所致恶心、呕吐的临床观察.doc

托烷司琼预防含顺钠化疗药物所致恶心、呕叶的临床观察[摘耍]H的:观察托烷司琼预防含顺釦化疗药物所致恶心、呕叶的疗效和不良反应。方法:将入选62例接受含顺钳联合化疗的恶性肿瘤患者,随机分成两组,,对照组30例病人使用昂丹司琼。观察两组病人恶心、呕吐的控制情况及不良反应。结果:托烷司琼和昂丹司琼预防化疗后恶心、呕吐的有效率无明显差界(P>);但完全控制率托烷司琼优于昂丹司琼(P〈)。两组不良反应发牛率无明显差异。结论:托烷司琼能有效预防含顺钳化疗药物所致恶心、呕吐,安全性好。[关键词]托烷司琼;昂丹司琼;化疗;恶心、呕吐[[文献标识码]A[文章编号11673-7210(2007)03(c)-014-02ClinicalobservationoftropisetroninpreventingnauseaandvomitinginduceclbychemotherapeuticdrugsincludingcisplainWANGJin-cai,ZHENGJi-hai,LIXiao-rui(TheFirstAffiliatedHospitalofXinxiangMedicalCollege,Weihui53100,Chian)[Abstract]0bjective::32patientswithcancerundergoingchemotherapyregimensincludingcisplainweredividedrandomlyinto2groups(observativegroupwasgiventropisetronbeforechemotherapyandcontrolgroupwasgivenondansetron).Thesituationofnausea,:Therewasnosignificantdifferenceinthetotaleffectiveratebetweentropisetronandondansetroninpreventingnauseaandvomitinginducedbychemotherapy(P>).pletecontrolrate(P<).Therewasnosignificantdiffereneeintheadversereactionsbetweentropisetronandondansetron(P>).Conclusion:Tropisetronwassafeandeffectiveinpreventingnauseaandvomitinginducedbychemotherapeuticdrugsincludingcisplain.[KeyWords]Tropisetron;0ndanse