UCP2在硫酸吲哚酚诱导心肌细胞肥大中的作用与机制研究.pdf

第三军医大学硕士学位论文英文简写 CKD CVD LVH IS UCP2 ATP ADP AMPK AICAR ROS ANF BNP MAPK p-MHC GAPDH NADPH NOX NAC OD JAK STAT PCR PBS 缩略语表英文全称中文全称 Chronic kidney disease 慢性肾脏病 Cardiovascular disease 心血管疾病 LeR ventricular hypenrophy 左室肥大 Indoxyl sulfate 硫酸吲哚酚 Uncoupling protein 2 解偶联蛋白2 Adenosine triphosphate 三磷酸腺苷 Adenosine diphosphate 二磷酸腺苷 AMP activated protein kinaSe 腺苷酸活化蛋白激酶 5一氨基咪唑一4一甲酰胺核苷酸转甲酰酶 I沁aCtive oxidative species 活性氧 Atrialnatriuretic factor 心房利钠肽 Brain natriuretic peptide 脑钠肽 Mitogen activated protein kinase 丝裂素活化蛋白激酶 p-myosin heaVy chain Glyceraldehyde-3-phosphate dehydrogenase 甘油醛-3-磷酸脱氢酶嘶phosphopyridine nucleotide 烟酰胺腺嘌呤二核苷酸磷酸 NADPH oxidase NADPH氧化酶 N-acet),l-L-cysteine 2’,7’.Dichloronuorescin diacetate 0pticaldens时光密度 JaJlusKinase 两面神激酶 Sigllaltmsducers aJldactivators of 信号传导及转录激活因子 transcription PolymeraSe chain reaction 聚合酶链反应 Phosphate bu舵r solution 磷酸盐缓冲液万方数据第三军医大学硕士学位论文 FBS BSA 嘶s DAPI PMSF SDS PAGE TEMED APS DEPC ddH20 HRP Rpm h Min Sec SOD F’etalbovlne seIum Bovine senlrn albumin Trihydroxymethyl锄inomethane 4’,6-diamidino一2一phenylindole Phenylmetllanesulfonyl fluoride Sodi啪dodecyl sulf-ate Polyacryl锄ide gelelectrophoresis Tetr锄emylethylenedi锄ine Ammonium Diethyl pyrocarbonate double distiUed H20 Horseradish peroxidase ReVolutions per minute Hour Minute Second Superoxide DismutaSe 2 胎牛血清牛血清白蛋白三羟甲基氨基甲烷 4, Ef|fects ofUCP2 on inhibiting cardiomyocyte hypertrophy induced by IS Abstract CaurdioVascular disease(CVD)is plication andtheleading cause ofmortality inpatients with chrollic kidney disease(CKD).With me improVement of dialysisteclulology,uremia patients haVe longer surviVal time,whjle thetimehe积exposed to uremia haVe also extended aCcordingly. Myocardial hypenrophy, the prominem pathological feature ofuremic cardiomyopathy,is important cause of